Volker M Arlt Selected Research

Balkan Nephropathy (Balkan Endemic Nephropathy)

9/2021	Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats.
1/2019	Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid.
10/2017	DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer.
4/2017	Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.
1/2017	Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.
2/2016	Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo.
2/2016	Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.
11/2015	A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.
11/2015	The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.
1/2015	The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy.

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Volker M Arlt Research Topics

Disease

63	Neoplasms (Cancer) 09/2021 - 07/2002
28	Balkan Nephropathy (Balkan Endemic Nephropathy) 09/2021 - 10/2002
18	Carcinogenesis 01/2019 - 07/2002
14	Body Weight (Weight, Body) 01/2019 - 01/2003
8	Lung Neoplasms (Lung Cancer) 12/2020 - 11/2005
7	Carcinoma (Carcinomatosis) 11/2015 - 02/2003
6	Fibrosis (Cirrhosis) 01/2016 - 04/2003
3	Breast Neoplasms (Breast Cancer) 02/2019 - 04/2004
3	Renal Insufficiency (Renal Failure) 03/2013 - 02/2003
3	Hepatocellular Carcinoma (Hepatoma) 03/2013 - 04/2007
2	Urinary Bladder Neoplasms (Bladder Cancer) 01/2021 - 01/2018
2	Neuroblastoma 01/2019 - 01/2018
2	Inflammation (Inflammations) 01/2019 - 08/2015
2	Acute Kidney Injury (Acute Renal Failure) 01/2016 - 11/2012
2	Atrophy 01/2016 - 11/2012
2	Chronic Kidney Failure (Chronic Renal Failure) 03/2009 - 02/2005
1	Lipidoses 02/2021
1	Kidney Diseases (Kidney Disease) 12/2019
1	Glycosuria 11/2019
1	Neoplasm Metastasis (Metastasis) 02/2019
1	Cicatrix (Scar) 01/2016
1	Splenomegaly 01/2016
1	Pneumonia (Pneumonitis) 08/2015
1	Carcinoma in Situ 02/2015
1	Non-Muscle Invasive Bladder Neoplasms 02/2015
1	Chromosome Aberrations (Chromosome Abnormalities) 03/2013
1	Edema (Dropsy) 11/2012

Drug/Important Bio-Agent (IBA)

50	aristolochic acid I (aristolochic acid)IBA 09/2021 - 07/2002
28	DNA AdductsIBA 01/2019 - 07/2002
17	CarcinogensIBA 01/2018 - 10/2006
11	DNA (Deoxyribonucleic Acid)IBA 11/2019 - 04/2004
9	EnzymesIBA 10/2017 - 03/2006
8	Benzo(a)pyreneIBA 02/2016 - 01/2008
6	Biomarkers (Surrogate Marker)IBA 02/2021 - 01/2007
6	ellipticineIBA 02/2019 - 02/2008
5	Plant ExtractsIBA 09/2021 - 11/2005
5	Codon (Codons)IBA 01/2021 - 04/2004
5	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 10/2019 - 06/2008
5	Pharmaceutical PreparationsIBA 02/2019 - 07/2002
5	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2018 - 03/2006
5	MutagensIBA 06/2010 - 01/2009
4	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 01/2021 - 08/2010
4	3-nitrobenzanthroneIBA 06/2010 - 11/2005
3	Biological ProductsIBA 01/2019 - 01/2007
3	AlkaloidsIBA 10/2017 - 11/2015
3	SmokeIBA 11/2012 - 06/2010
3	Vehicle Emissions (Emissions, Vehicle)IBA 10/2009 - 11/2005
2	Aristolochic AcidsIBA 09/2021 - 02/2009
2	Environmental CarcinogensIBA 01/2021 - 06/2010
2	A-Form DNA (A-DNA)IBA 02/2019 - 11/2011
2	MicroRNAs (MicroRNA)IBA 01/2019 - 09/2013
2	CytochromesIBA 01/2019 - 04/2011
2	Particulate MatterIBA 01/2018 - 06/2008
2	Oxidoreductases (Dehydrogenase)IBA 01/2018 - 03/2006
2	dibenzo(a,l)pyreneIBA 01/2016 - 11/2012
2	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2016 - 04/2011
2	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 08/2015 - 04/2007
2	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideIBA 03/2015 - 01/2008
1	Mechanistic Target of Rapamycin Complex 1IBA 02/2021
1	LipofuscinIBA 02/2021
1	4-biphenylamineIBA 01/2021
1	2- hydroxyamino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 01/2021
1	glycidamideIBA 12/2020
1	Adenine FDA LinkGeneric 12/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2019
1	SulfotransferasesIBA 10/2019
1	1-hydroxymethylpyreneIBA 10/2019
1	Antineoplastic Agents (Antineoplastics)IBA 02/2019
1	ApoferritinsIBA 01/2019
1	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA 01/2019
1	N'-nitrosonornicotine (nitrosonornicotine)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	LipidsIBA 01/2019
1	NitrosaminesIBA 01/2019
1	SteroidsIBA 01/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2018
1	Histone Deacetylase InhibitorsIBA 01/2018
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2018
1	Phenobarbital (Luminal)FDA Link 01/2018
1	Keratin-5 (Keratin 5)IBA 01/2018
1	Persistent Organic PollutantsIBA 01/2018
1	XenobioticsIBA 01/2018
1	ProdrugsIBA 01/2018
1	NucleotidesIBA 01/2018
1	IronIBA 01/2016
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016
1	LipopolysaccharidesIBA 08/2015
1	Air Pollutants (Pollutants, Air)IBA 08/2015
1	Heavy MetalsIBA 01/2015
1	IonsIBA 01/2015
1	ochratoxin AIBA 01/2015
1	Cytochromes b5 (Cytochrome b5)IBA 12/2014
1	pyreneIBA 10/2014
1	Messenger RNA (mRNA)IBA 09/2013
1	Glucose (Dextrose)FDA LinkGeneric 09/2013

Therapy/Procedure

3	Therapeutics 01/2018 - 07/2005
1	Lasers (Laser) 01/2019
1	Intravesical Administration 02/2015
1	Kidney Transplantation 02/2015